UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549



                                  SCHEDULE 13G

                   Under the Securities Exchange Act of 1934*

                                (Amendment No. 2)

                                    GTx, Inc.
                                    ---------
                                (Name of Issuer)

                         Common Stock, $0.001 par value
                         ------------------------------
                         (Title of Class of Securities)

                                    40052B108
                                    ---------
                                 (CUSIP Number)

                                December 31, 2007
                                -----------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                                [ ] Rule 13d-1(b)
                                [X] Rule 13d-1(c)
                                [ ] Rule 13d-1(d)

  *The remainder of this cover page shall be filled out for a reporting person's
  initial filing on this form with respect to the subject class of securities,
  and for any subsequent amendment containing information which would alter the
  disclosures provided in a prior cover page.

  The information required on the remainder of this cover page shall not be
  deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
  Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
  the Act but shall be subject to all other provisions of the Act (however, see
  the Notes).







- ------------------------------                               -------------------
CUSIP No. 40052B108                       13G                Page 2 of 6 Pages
- ------------------------------                               -------------------

- ---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Larry N. Feinberg
- ---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a) [ ]
                                                                       (b) [X]
- ---------- ---------------------------------------------------------------------
3          SEC USE ONLY
- ---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
- -------------------- ------ ----------------------------------------------------
                     5      SOLE VOTING POWER

                            0
                     ------ ----------------------------------------------------
     NUMBER OF       6      SHARED VOTING POWER
      SHARES
   BENEFICIALLY             2,306,038
     OWNED BY
       EACH          ------ ----------------------------------------------------
     REPORTING       7      SOLE DISPOSITIVE POWER
      PERSON
       WITH                 0
                     ------ ----------------------------------------------------
                     8      SHARED DISPOSITIVE POWER

                            2,306,038
- ---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2,306,038
- ---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

           N/A
- ---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           6.6%
- ---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON*

           IN
- ---------- ---------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

                                      -2-




- ------------------------------                               -------------------
CUSIP No. 40052B108                       13G                Page 3 of 6 Pages
- ------------------------------                               -------------------

- ---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Oracle Investment Management, Inc.
- ---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a) [ ]
                                                                       (b) [X]
- ---------- ---------------------------------------------------------------------
3          SEC USE ONLY
- ---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
- -------------------- ------ ----------------------------------------------------
                     5      SOLE VOTING POWER

                            0
                     ------ ----------------------------------------------------
     NUMBER OF       6      SHARED VOTING POWER
      SHARES
   BENEFICIALLY             1,588,997
     OWNED BY
       EACH          ------ ----------------------------------------------------
     REPORTING       7      SOLE DISPOSITIVE POWER
      PERSON
       WITH                 0
                     ------ ----------------------------------------------------
                     8      SHARED DISPOSITIVE POWER

                            1,588,997
- ---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,588,997
- ---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

           N/A
- ---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           4.6%
- ---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON*

           CO
- ---------- ---------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

                                      -3-







This Amendment No. 2 to Schedule 13G (this "Amendment No. 2") is being filed
with respect to the Common Stock of GTx, Inc., a Delaware corporation (the
"Company"), to amend the Amendment No. 1 to Schedule 13G filed on February 7,
2006 (the "Amendment No. 1"). Capitalized terms used but not defined herein have
the meaning ascribed thereto in the Amendment No. 1.

Item 4:   Ownership:
- ------    ---------

     Item 4 of the Amendment No. 1 is hereby amended by the deletion of the
entirety of the text thereof and its replacement with the following:

     The percentages used herein and in the rest of this Amendment No. 2 are
calculated based upon 34,922,124 shares of Common Stock issued and outstanding
as of November 8, 2007 as reported in the Company's Quarterly Report on Form
10-Q for the quarterly period ended September 30, 2007. The beneficial ownership
of each of the Reporting Persons is set forth below.

  A. Larry N. Feinberg
     -----------------
     (a) Amount beneficially owned: 2,306,038
     (b) Percent of class: 6.6%.
     (c) Number of shares as to which such person has:
          (i) Sole power to vote or direct the vote: 0
          (ii) Shared power to vote or direct the vote: 2,306,038
          (iii) Sole power to dispose or direct the disposition: 0
          (iv) Shared power to dispose or direct the disposition: 2,306,038

  B. Oracle Investment Management, Inc.
     ----------------------------------
     (a) Amount beneficially owned: 1,588,997
     (b) Percent of class: 4.6%.
     (c) Number of shares as to which such person has:
          (i) Sole power to vote or direct the vote: 0
          (ii) Shared power to vote or direct the vote: 1,588,997
          (iii) Sole power to dispose or direct the disposition: 0
          (iv) Shared power to dispose or direct the disposition: 1,588,997

Item 5:   Ownership of Five Percent or Less of a Class:
- ------    --------------------------------------------

     Item 5 of the Amendment No. 1 is hereby amended by the deletion of the
entirety of the text thereof and its replacement with the following:

     If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities, check the following: [X]

     As of the date hereof, the Investment Manager has ceased to be the
beneficial owner of more than five percent of the Common Stock. As of the

                                      -4-


date hereof, Mr. Feinberg continues to be the beneficial owner of more than five
percent of the Common Stock.

Item 10:  Certification:
- -------   -------------

     Each of the Reporting Persons hereby makes the following certification:

          By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.

              [THE REMAINDER OF THIS PAGE LEFT INTENTIONALLY BLANK]


                                      -5-











                                    SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

DATED:  February 14, 2008


                                  ORACLE INVESTMENT MANAGEMENT, INC.



                                  By: /s/ Larry N. Feinberg
                                      ------------------------------------------
                                      Name: Larry N. Feinberg
                                      Title: President


                                  /s/ Larry N. Feinberg
                                  ----------------------------------------------
                                  Larry N. Feinberg







                               [SIGNATURE PAGE TO
                         AMENDMENT NO. 2 TO SCHEDULE 13G
                           WITH RESPECT TO GTX, INC.]