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ONCTERNAL therapeutics P.O. BOX 8016, CARY, NC 27512-9903 Oncternal Therapeutics, Inc. Important Notice Regarding the Availability of Proxy Materials Stockholders Meeting to be held on May 25, 2021 For Stockholder as of record on March 26, 2021 This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. This is not a ballot. You cannot use this notice to vote your shares. We encourage you to access and review all of the important information contained in the proxy materials before voting. To view the proxy materials, and to obtain directions to attend meeting, go to: www.proxydocs.com/ONCT To vote your proxy while visiting this site, you will need the 12 digit control number in the box below. Under United States Securities and Exchange Commission rules, proxy materials do not have to be delivered in paper. Proxy materials can be distributed by making them available on the internet. For a convenient way to view proxy materials and VOTE go to www.proxydocs.com/ONCT Have the 12 digit control number located in the shaded box above available when you access the website and follow the instructions. If you want to receive a paper or e-mail copy of the proxy material, you must request one. There is no charge to you for requesting a copy. In order to receive a paper package in time for this year’s meeting, you must make this request on or before May 14, 2021. To order paper materials, use one of the following methods.INTERNET www.investorelections.com/ONCT TELEPHONE (866) 648-8133 * E-MAIL paper@investorelections.com When requesting via the internet or telephone you will need the 12 digit control number located in the shaded box above.* If requesting material by e-mail, please send a blank e-mail with the 12 digit control number (located above) in the subject line. No other requests, instructions OR other inquiries should be included with your e-mail requesting material. Oncternal Therapeutics, Inc. Meeting Type: Annual Meeting of Stockholders Date: Tuesday, May 25, 2021 Time: 08:00 AM, PDT Place: Annual Meeting to be held live via the Internet. Please visit www.proxydocs.com/ONCT for more details. You must register to attend the meeting online and/or participate at www.proxydocs.com/ONCT SEE REVERSE FOR FULL AGENDA








Oncternal Therapeutics, Inc. Annual Meeting of Stockholders THE BOARD OF DIRECTORS RECOMMENDS A VOTE: FOR ON PROPOSALS 1, 2 AND 3 PROPOSAL 1. Election of Directors 1.01 Jinzhu Chen, Ph.D. 1.02 Xin Nakanishi, Ph.D. 1.03 Robert J. Wills, Ph.D. 2. Ratification of the appointment of BDO USA, LLP as our independent registered public accounting firm for the year ending December 31, 2021. 3. Approve an amendment to our Restated Certificate of Incorporation to increase the authorized number of shares of common stock from 60,000,000 to 120,000,000. Also includes authorization to vote upon such other business as may properly come before the meeting at any adjournment or postponement thereof.