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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934*
Amendment No. 1
GTx, Inc.
---------
(Name of Issuer)
Common Stock, $0.001 par value
------------------------------
(Title of Class of Securities)
40052B108
---------
(CUSIP Number)
December 31, 2005
-----------------
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:
[ ] Rule 13d-1(b)
[ ] Rule 13d-1(c)
[X] Rule 13d-1(d)
*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).
- ----------------------------------------- ---------------------------
CUSIP No. 40052B108 13G Page 2 of 6 Pages
- ----------------------------------------- ---------------------------
- ---------- ---------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Larry N. Feinberg
- ---------- ---------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [X]
- ---------- ---------------------------------------------------------------------
3 SEC USE ONLY
- ---------- ---------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- -------------------- ------ ----------------------------------------------------
5 SOLE VOTING POWER
0
------ ----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 2,441,973
OWNED BY
EACH ------ ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH 0
------ ----------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,441,973
- ---------- ---------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,441,973
- ---------- ---------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
N/A
- ---------- ---------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
7.9%
- ---------- ---------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- ---------- ---------------------------------------------------------------------
*SEE INSTRUCTION BEFORE FILLING OUT!
- ----------------------------------------- ---------------------------
CUSIP No. 40052B108 13G Page 3 of 6 Pages
- ----------------------------------------- ---------------------------
- ---------- ---------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Oracle Investment Management, Inc.
- ---------- ---------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [X]
- ---------- ---------------------------------------------------------------------
3 SEC USE ONLY
- ---------- ---------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- -------------------- ------ ----------------------------------------------------
5 SOLE VOTING POWER
0
------ ----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 1,819,070
OWNED BY
EACH ------ ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH 0
------ ----------------------------------------------------
8 SHARED DISPOSITIVE POWER
1,819,070
- ---------- ---------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,819,070
- ---------- ---------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
N/A
- ---------- ---------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
5.9%
- ---------- ---------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
OO
- ---------- ---------------------------------------------------------------------
*SEE INSTRUCTION BEFORE FILLING OUT!
This Amendment No. 1 to Schedule 13G (this "Amendment No. 1") is being filed
with respect to the Common Stock of GTx, Inc., a Delaware corporation (the
"Company"), to amend the Schedule 13G filed on February 9, 2005 (the "Schedule
13G"). Capitalized terms used but not defined herein have the meaning ascribed
thereto in the Schedule 13G.
Item 2(a): Name of Person Filing:
- --------- ---------------------
Item 2(a) of the Schedule 13G is hereby amended by the deletion of the
entirety of the text thereof and its replacement with the following:
This statement is filed by :
i) Oracle Investment Management, Inc., a Delaware corporation (the
"Investment Manager"), which serves as investment manager to and has
investment discretion over the securities held by certain investment
funds and/or managed accounts (the "Foreign Funds"), with respect to
shares of Common Stock directly owned by it and by the Foreign Funds;
and
ii) Mr. Larry N. Feinberg ("Mr. Feinberg"), who A) serves as the senior
managing member of Oracle Associates, LLC, a Delaware limited
liability company ("Oracle Associates"), which serves as the general
partner of certain investment funds and/or managed accounts (the
"Domestic Funds," and together with the Foreign Funds, the "Funds"),
and B) is the sole shareholder and president of the Investment
Manager, with respect to shares of Common Stock directly owned by the
Funds and the Investment Manager.
Mr. Feinberg and the Investment Manager are hereinafter sometimes
collectively referred to as the "Reporting Persons." Any disclosures herein with
respect to persons other than the Reporting Persons are made on information and
belief after making inquiry to the appropriate party.
- 4 -
Item 4: Ownership:
- ------ ----------
Item 4 of the Schedule 13G is hereby amended by the deletion of the
entirety of the text thereof and its replacement with the following:
The percentages used herein and in the rest of this Amendment No. 1 are
calculated based upon the 30,992,550 shares of Common Stock issued and
outstanding as of November 4, 2005 as reported in the Company's Report on Form
10-Q for the quarterly period ended September 30, 2005. The beneficial ownership
of each of the Reporting Persons is set forth below.
A. Larry N. Feinberg
-----------------
(a) Amount beneficially owned: 2,441,973
(b) Percent of class: 7.9%.
(c) Number of shares as to which such person has:
(i) Sole power to vote or direct the vote: 0
(ii) Shared power to vote or direct the vote: 2,441,973
(iii) Sole power to dispose or direct the disposition: 0
(iv) Shared power to dispose or direct the disposition: 2,441,973
B. Oracle Investment Management, Inc.
----------------------------------
(a) Amount beneficially owned: 1,819,070
(b) Percent of class: 5.9%.
(c) Number of shares as to which such person has:
(i) Sole power to vote or direct the vote: 0
(ii) Shared power to vote or direct the vote: 1,819,070
(iii) Sole power to dispose or direct the disposition: 0
(iv) Shared power to dispose or direct the disposition: 2,441,973
Item 10: Certification:
- ------- --------------
The Reporting Person hereby makes the following certification:
By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were not acquired and are not held for the
purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.
[THE REMAINDER OF THIS PAGE LEFT INTENTIONALLY BLANK]
- 5 -
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.
DATED: February 7, 2006
/s/ Larry N. Feinberg
----------------------------------------------
Larry N. Feinberg
ORACLE INVESTMENT MANAGEMENT, INC.
By: /s/ Larry N. Feinberg
-----------------------------------------
Name: Larry N. Feinberg
Title: President
[SIGNATURE PAGE TO
AMENDMENT NO. 1 TO SCHEDULE 13G
WITH RESPECT TO GTX, INC.]